A team of scientists from Nanyang Technological University has made significant progress in understanding the complex processes involved in wound healing. The study reveals that certain wounds, such as those on the lower limbs or with a history of previous trauma, are more likely to be resistant to treatment. This is due to a combination of factors, including inadequate blood supply, excessive inflammation, and the presence of biofilms - communities of microorganisms that adhere to tissues.
The researchers found that these underlying causes can lead to a vicious cycle, where persistent inflammation prevents wounds from healing properly, while also creating an environment conducive to further microbial growth. This understanding has important implications for developing targeted treatments for intractable wounds, which currently account for a significant proportion of healthcare costs and morbidity worldwide. Further research is needed to explore the potential applications of this knowledge in improving wound care outcomes.
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